Research topics in Metabolomics
From EESwiki
We are presently setting up a new group in metabolic research, with different partners from Helmholtz Zentrum München institutes. My present personal interest is in genetically determined human metabotypes and their link to complex diseases, such as type 2 diabetes. Metabolomics studies in animal models, such as mice and bovine are used in complement to studies in the human population. As a bioinformatician, I combine data from different sources, many of them from local Helmholtz Muenchen instruments, such as targeted quantitative metabolomics from an ABI QTRAP 4000, non-targeted metabolomics from a Bruker 12 Tesla APEX FT-ICR, and genotyping information using Affymetrix 500k GeneChip arrays in the KORA population. Research topics for interested students can be offered in the range from a more biology-driven question (e.g. analysis of a specific metabolomics dataset) to a more methodology-driven topic (e.g. development of new algorithms for metabolomics data analysis). A strong background in informatics is required (R and perl, preferentially under Linux). Wet lab work is not foreseen, but can be discussed with candidates with a strong background in mass spectrometry. Place of work would be at the Helmholtz Zentrum Muenchen in Neuherberg.
References:
- Altmaier et al., Bioinformatics analysis of targeted metabolomics - uncovering old and new tales of diabetic mice under medication, Endocrinology, in press
- http://www.masstrix.org
- http://mips.gsf.de/staff/suhre/
