Lena Müller

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Dipl. biol. Lena Müller

Section of Evolutionary Biology
LMU BioCenter
Grosshaderner Str. 2
82152 Planegg-Martinsried
Germany

E-Mail: lmueller@biologie.uni-muenchen.de

My PhD thesis

Gene expression variation in natural populations of Drosophila

Recent advances in genomic technologies have enabled global analyses of gene expression variation among individuals of a species. A surprising finding has been that many species harbour vast amounts of gene expression variation. The goal of this project is the evolutionary and functional analysis of genes showing significant expression variation within and between populations of the fruit fly Drosophila melanogaster. The objectives include: 1) microarray experiments to determine gene expression variation in two natural populations, 2) population genetic analyses of coding and regulatory sequences to elucidate the roles of selection, drift, and demography in the maintenance of gene expression variation, and 3) transgenic experiments to functionally test the effects of putative cis-regulatory variants on gene expression.